\documentclass[border=2mm]{standalone}
\usepackage{pgfplots}
\usepackage{amsmath}
\usepackage[utf8]{inputenc}
\pgfplotstableread{
Century Manuscripts Books
6       13552           nan
7       10639           nan
8       43702           nan
9       201742  nan
10      135637  nan
11      212030  nan
12      768721  nan
13      1761951 nan
14      2746951 nan
15      4999161 12589000
16       nan            217444000
17      nan             531941000
18      nan             983874000
}\datatable
 
\definecolor{RYB2}{RGB}{253, 180, 98}
 
 
\begin{document}
\begin{tikzpicture}
  \begin{axis}[
        x=0.7895cm,
        axis on top=false, grid=both, xmajorgrids=false, xminorgrids=false, every minor grid/.style=gray!20,
        minor y tick num=4,
        axis lines*=left,
        width=12cm, height=8cm, enlarge x limits=0.05,
        ymin=0, ymax=5e6, scaled y ticks=false,
        ytick={0,1e6,2e6,3e6,4e6,5e6},
        yticklabels={0,1\,000\,000,2\,000\,000,3\,000\,000, 4\,000\,000,5\,000\,000},
        enlarge y limits=false,
        ybar=-10pt, xtick={6,...,18}, xticklabel={\pgfmathparse{int(\tick)}\pgfmathresult.},
        xlabel=Jahrhundert, xlabel style={yshift=-1ex},ylabel=Anzahl der\\Exemplare,
         ylabel style={rotate=-90, align=left, anchor=east, xshift=-4ex, name=ylabel},
        title={Europäische Produktion von Manuskripten 500--1500$^{\text{\tiny{*}}}$},
        title style={font=\large\bfseries, align=center}
        ]
 
\addplot +[fill=RYB2, draw=RYB2!50!black] table {\datatable};
\draw (rel axis cs:0,0) -- (rel axis cs:1,0);                 
  \end{axis}
\node (annotation) at (current axis.below south west) [inner xsep=0pt, anchor=north west, align=left, font=\tiny] {$^*$ohne Südosteuropa (byzantinischer Bereich) und Russland};
 
  \end{tikzpicture}
\end{document}